Description

ZO Skin Health Peptide Facial Refining Concentrate — The 4-Peptide Serum That Defines and Refines Facial Contours

ZO Skin Health Peptide Facial Refining Concentrate is the most advanced peptide serum launched by the brand founded by Dr. Zein Obagi, a pioneer of modern cosmetic dermatology. Formulated with four synergistic peptide technologies and the patented ZPOLY™ complex, this serum is designed to restore the skin’s visible architecture — not merely to mask the signs of aging, but to target facial contours, volume, and expression lines.

Why This Serum Is Different from Anything You’ve Tried Before

Most peptide serums contain one or two active ingredients that target a single concern. ZO Peptide Facial Refining Concentrate combines four different peptide families, each with a specific role, working together to visibly restore the skin’s structure on three levels: muscle activity, dermal matrix, and volume.
Essentially, it is a cosmetic designed to complement the effects of botulinum toxin and dermal filler treatments — without needles, without downtime, and easily incorporated into your daily skincare routine.

The 4 Peptide Technologies in the Formula

Acetyl Octapeptide-3 — A neuropeptide that visibly modulates muscle contractions. It smooths dynamic expression lines (frown lines, crow’s feet, and forehead lines) through a topical mechanism similar to that of botulinum toxin. It is particularly effective on the forehead and around the eyes.

Acetyl Hexapeptide-8 — Works synergistically with Acetyl Octapeptide-3 to reduce the appearance of deep static wrinkles (wrinkles that remain visible even when the face is at rest) and supports the integrity of the dermal matrix and the skin’s natural firmness.

Refining Peptide Complex — комплекс из двух активных пептидов (пальмитоил-дипептид-5-диаминобутироилгидрокситреонин + пальмитоил-дипептид-5-диаминогидроксибутират), который корректирует изменения геометрии лица и способствует заметной структурной ремоделировке. Результат: более четкие контуры, более скульптурный и выразительный облик.

Volumizing Tripeptide — A unique tripeptide that stimulates the skin’s natural production of hyaluronic acid, visibly restoring volume in areas affected by volume loss (cheeks, temples, and jawline) and bringing back a plump, youthful, well-rested appearance.

ZPOLY™ Complex — ZO’s signature complex for healthy, resilient skin.

ZPOLY™ is a patented, plant-derived complex developed exclusively by ZO Skin Health. In this formula, it helps provide intense hydration, soothe visible redness, strengthen the skin’s protective barrier, and protect against the signs of premature aging. In a clinical study, 92% of users reported a feeling of comfort for sensitive or redness-prone skin.

This balance of active peptides and a soothing complex allows the serum to be used daily, even on sensitive skin, without irritation or reactivity.

A Daily Alternative or the Perfect Complement to Professional Treatments

ZO Peptide Facial Refining Concentrate was designed for use in two complementary scenarios:

As a daily topical alternative to injectable treatments — for those who prefer a gradual cosmetic approach, without needles or downtime. Results develop progressively but are visible and, according to the study, are perceived as natural and harmonious.

As a supportive treatment between botulinum toxin and dermal filler sessions — the serum helps maintain skin comfort and a smoother texture between clinic visits, providing continuity of care at home.

This is a refining concentrate, not just a hydrating peptide serum. Designed to be the key step in your morning and evening skincare routine, it helps redefine your results over the long term.

Who Is It Recommended For?

The serum is suitable for all skin types, is alcohol-free and fragrance-free, and has been tested on sensitive skin as well. It is recommended if you experience one or more of the following concerns:

Dynamic wrinkles (forehead lines, frown lines, and crow’s feet)

Deep static wrinkles, visible even when the face is at rest.

Loss of firmness and skin laxity.

Changes in facial contours — hollow cheeks, a less defined jawline, and volume loss in the temples.

Skin lacking firmness and definition, with a tired appearance.

Visible redness or reactive skin.

The desire to delay, reduce, or complement injectable treatments with a clinically tested topical alternative.

How to use

Cleanse the skin with a gentle cleanser from the ZO Getting Skin Ready® range or an equivalent product.

Apply 1–2 pumps to the dry face, neck, and décolleté, morning and evening.

Massage using upward and outward strokes, moving from the center of the face toward the outer contours, until fully absorbed. Focus on the jawline, cheeks, and temples.

Continue with the rest of your ZO skincare routine (moisturizer, active treatments, and sunscreen).

Morning routine: Always finish with SPF 30+ or SPF 50 sunscreen (Sheer Fluid Broad-Spectrum Sunscreen SPF 50 is recommended).

Professional tip: Peptides combine well with other active ingredients, including retinol, vitamin C, and growth factors. If you use retinol in the evening, apply ZO Peptide Facial Refining Concentrate first (peptides require a neutral pH), then apply retinol once the serum has been fully absorbed.

Can it be combined with botulinum toxin and dermal filler treatments?

Yes, it is specifically formulated for this purpose. ZO Peptide Facial Refining Concentrate can be used between injectable treatment sessions to maintain skin comfort and help support the appearance of the results. Avoid applying the serum to treated areas for the first 24–48 hours after injections, or as directed by your aesthetic physician.

Full Ingredients List (INCI)

Aqua/Water/Eau, Glycerin, Propanediol, Acetyl Octapeptide-3, Acetyl Hexapeptide-8, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Dipeptide-5 Diaminohydroxybutyrate, Laminaria Digitata Extract, Opuntia Ficus-Indica Stem Extract, Tocopherol, Caprylyl Glycol, Hexylene Glycol, Sodium Hyaluronate, Galactoarabinan, Schizophyllan, Tetradecyl Aminobutyroyl/Valylaminobutyric Urea Trifluoroacetate, Beta-Sitosterol, Lecithin, Hydrogenated Phosphatidylcholine, Lysolecithin, Carbomer, Xanthan Gum, Magnesium Chloride, Disodium EDTA, Phytic Acid, Maltodextrin, Squalene, Aminomethyl Propanol, Citric Acid, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate, Potassium Sorbate.

Warnings and Storage

Avoid contact with the eyes; if contact occurs, rinse thoroughly with water. For sensitive skin, perform a patch test before first full use. During pregnancy or breastfeeding, consult your physician before use. Keep out of reach of children. Store at room temperature (15–25°C), away from direct sunlight, with the cap tightly closed.